The Four Dharma Seals are suffering, impermanence, no-self and nirvana.
The second and third are the crucible of our lives. If we think of the self as real, fixed, permanent, then the unavoidable truth of impermanence will cause us to suffer. We are always one step closer to falling.
If we see the insubstantiality of the self, that is the liberation of all beings. Impermanence can then be seen as the dynamic functioning of interconnectedness, and we can live at peace with all sentient beings, undarkening the world by no longer throwing the dust of the self over it.
We have a choice. We either fall down or stand up. And, of course, we do both.